Although inhibitory inputs are often viewed as equal but opposite to excitatory inputs, excitatory inputs may alter the firing of postsynaptic cells more effectively than inhibitory inputs. This is because spike cancellation produced by an inhibitory input requires coincidence in time, whereas an excitatory input can add spikes with less temporal constraint. To test for such potential differences, especially in the context of the function of thalamocortical (TC) relay nuclei, we used a stochastic “integrate-and-fire-or-burst” TC neuron model to quantify the detectability of excitatory and inhibitory drive in the presence and absence of the low-threshold ...
The Journal of Neuroscience
Smith, Gregory D. and Sherman, S Murray, Detectability of excitatory vs. inhibitory drive in a thalamocortical relay neuron model. (2001). The Journal of Neuroscience, 22(23).