emb-1 Encodes the APC16 Subunit of the Caenorhabditis elegans Anaphase-Promoting Complex
In the nematode Caenorhabditis elegans, temperature-sensitive mutants of emb-1 arrest as one-cell embryos in metaphase of meiosis I in a manner that is indistinguishable from embryos that have been depleted of known subunits of the anaphase-promoting complex or cyclosome (APC/C). Here we show that the emb-1 phenotype is enhanced in double mutant combinations with known APC/C subunits and suppressed in double mutant combinations with known APC/C suppressors. In addition to its meiotic function, emb-1 is required for mitotic proliferation of the germline. These studies reveal that emb-1 encodes K10D2.4, a homolog of the small, recently discovered APC/C subunit, APC16.
Allen, Anna K.; Golden, Andy; Shakes, Diane C.; and Albert, Kelsey M., emb-1 Encodes the APC16 Subunit of the Caenorhabditis elegans Anaphase-Promoting Complex (2011). Genetics, 189(2), 549-560.