Title

emb-1 Encodes the APC16 Subunit of the Caenorhabditis elegans Anaphase-Promoting Complex

Document Type

Article

Department/Program

Biology

Journal Title

Genetics

Pub Date

2011

Volume

189

Issue

2

First Page

549

Abstract

In the nematode Caenorhabditis elegans, temperature-sensitive mutants of emb-1 arrest as one-cell embryos in metaphase of meiosis I in a manner that is indistinguishable from embryos that have been depleted of known subunits of the anaphase-promoting complex or cyclosome (APC/C). Here we show that the emb-1 phenotype is enhanced in double mutant combinations with known APC/C subunits and suppressed in double mutant combinations with known APC/C suppressors. In addition to its meiotic function, emb-1 is required for mitotic proliferation of the germline. These studies reveal that emb-1 encodes K10D2.4, a homolog of the small, recently discovered APC/C subunit, APC16.

DOI

10.1534/genetics.111.131714

This document is currently not available here.

Share

COinS