Document Type

Article

Department/Program

Applied Science

Department

Neuroscience

Journal Title

J Neurosci

Pub Date

3-21-2018

Volume

38

Issue

12

Journal Article URL

http://www.jneurosci.org/content/38/12/3039.long

Abstract

Brainstem neurons in the preBo¨tC generate the oscillatory activity that underlies breathing. PreBo¨tC neurons express voltagedependent currents that can influence inspiratory activity, among which is a transient potassium current (IA) previously identified in a rhythmogenic excitatory subset of type-1 preBo¨tC neurons. We sought to determine whether IA is expressed in the dendrites of preBo¨tC. We found that dendrites of type-1 preBo¨tC neurons indeed express IA, which may aid in shunting sparse non-summating synaptic inputs, while enabling strong summating excitatory inputs to readily pass and thus influence somatic membrane potential trajectory. The subcellular distribution of IA in rhythmically active neurons of the preBo¨tC may thus be critical for producing well coordinated ensemble activity during inspiratory burst formation.

DOI

https://doi.org/10.1523/JNEUROSCI.3342-17.2018

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