Document Type
Article
Department/Program
Chemistry
Journal Title
Molecules
Pub Date
2015
Volume
20
Issue
4
First Page
5276
Abstract
The translation of organometallic reactions into a microwave reactor has numerous advantages. Herein, we describe the application of a previously developed solid-supported Glaser-Hay reaction to microwave conditions. Overall, an array of diynes has been prepared demonstrating the ability to conduct chemoselective reactions in the microwave within 20 min compared to the 16 h thermal conditions. Moreover, non-microwave transparent alkynes have been found to react more quickly, preventing catalyst quenching, and resulting in higher yields.
Recommended Citation
Lampkowski, Jessica S.; Maza, Johnathan C.; Verma, Sanjana; and Young, Douglas D., Optimization of Solid-Supported Glaser-Hay Reactions in the Microwave (2015). Molecules, 20(4), 5276-5285.
10.3390/molecules20045276
DOI
10.3390/molecules20045276
