Thumbnail Image
Publication

Research needs for the risk assessment of health and environmental effects of endocrine disruptors: A report of the US EPA-sponsored workshop

Kavlock, RJ
; 
Daston, GP
; 
DeRosa, C
; 
FennerCrisp, P
; 
Gray, LE
; 
Kaattari, S
Abstract
The hypothesis has been put forward that humans and wildlife species have suffered adverse health effects after exposure to endocrine-disrupting chemicals. Reported adverse effects include declines in populations, increases in cancers, and reduced reproductive function. The U.S. Environmental Protection Agency sponsored a workshop in April 1995 to bring together interested parties in an effort to identify research gaps related to this hypothesis and to establish priorities for future research activities. Approximately 90 invited participants were organized into work groups developed around the principal reported health effects-carcinogenesis, reproductive toxicity, neurotoxicity, and immunotoxicity--as well as along the risk assessment paradigm--hazard identification, dose-response assessment, exposure assessment, and risk characterization. Attention focused on both ecological and human health effects. In general, the group felt that the hypothesis warranted a concerted research effort to evaluate its validity and that research should focus primarily on effects on development of reproductive capability, on improved exposure assessment, and on the effects of mixtures. This report summarizes the discussions of the work groups and details the recommendations for additional research.
Description
Date
1996-08-01
Journal Title
Journal ISSN
Volume Title
Publisher
Collections
Publications, Presentations, & Events
Show all metadata
Download Dataset
Files
Thumbnail Image
ehp.96104s4715.pdf
Adobe PDF, 5.87 MB
Rights Holder
Usage License
Embargo
Research Projects
Organizational Units
Journal Issue
Keywords
Aquatic Health Sciences Peer-Reviewed Articles, endocrine disruptors; hormones; risk assessment; carcinogenesis; reproductive toxicity; developmental toxicity; immunotoxicity
Citation
Advisor
Department
Virginia Institute of Marine Science
DOI
https://doi.org/10.1289/ehp.96104s4715
URI
https://scholarworks.wm.edu/handle/internal/17904
Embedded videos