Thumbnail Image
Publication

The Kinome of Pacific Oyster Crassostrea gigas, Its Expression during Development and in Response to Environmental Factors

Epelboin, Yanouk
; 
Quintric, Laure
; 
Guevelou, Eric
; 
Boudry, Pierre
; 
Pichereau, Vianney
; 
Corporeau, Charlotte
Abstract
Oysters play an important role in estuarine and coastal marine habitats, where the majority of humans live. In these ecosystems, environmental degradation is substantial, and oysters must cope with highly dynamic and stressful environmental constraints during their lives in the intertidal zone. The availability of the genome sequence of the Pacific oyster Crassostrea gigas represents a unique opportunity for a comprehensive assessment of the signal transduction pathways that the species has developed to deal with this unique habitat. We performed an in silico analysis to identify, annotate and classify protein kinases in C. gigas, according to their kinase domain taxonomy classification, and compared with kinome already described in other animal species. The C. gigas kinome consists of 371 protein kinases, making it closely related to the sea urchin kinome, which has 353 protein kinases. The absence of gene redundancy in some groups of the C. gigas kinome may simplify functional studies of protein kinases. Through data mining of transcriptomes in C. gigas, we identified part of the kinome which may be central during development and may play a role in response to various environmental factors. Overall, this work contributes to a better understanding of key sensing pathways that may be central for adaptation to a highly dynamic marine environment.
Description
Date
2016-01-01
Journal Title
Journal ISSN
Volume Title
Publisher
Collections
Publications, Presentations, & Events
Show all metadata
Download Dataset
Files
Thumbnail Image
kinome.PDF
Adobe PDF, 1.05 MB
Rights Holder
Usage License
Embargo
Research Projects
Organizational Units
Journal Issue
Keywords
Fisheries Science Peer-Reviewed Articles, ACTIVATED PROTEIN-KINASE; FACTOR-BETA SUPERFAMILY; LIGHT-CHAIN KINASE; CAENORHABDITIS-ELEGANS; TYROSINE KINASE; BIVALVE MOLLUSK; POSTTRANSLATIONAL MODIFICATIONS; DOPAMINERGIC-NEURONS; MOLECULAR-MECHANISMS; SIGNAL-TRANSDUCTION
Citation
Epelboin Y, Quintric L, Guévélou E, Boudry P, Pichereau V, Corporeau C (2016) The Kinome of Pacific Oyster Crassostrea gigas, Its Expression during Development and in Response to Environmental Factors. PLoS ONE 11(5): e0155435. doi:10.1371/journal.pone.0155435
Advisor
Department
Virginia Institute of Marine Science
DOI
https://doi.org/10.1371/journal.pone.0155435
URI
https://scholarworks.wm.edu/handle/internal/18443
Embedded videos