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Investigation of Unnatural Amino Acids as a Means to Modulate Protein Function

Jacobs, Taylor Harrison
Abstract
In order to elucidate the biological processes that occur in everyday life, chemical biologists have developed technologies that allow the study of a various biological systems. Bioorthogonal chemistry is an ever-growing technology that involves performing chemical reactions with biological systems that do not rely on existing biological chemistries. In this work we attempt to develop and characterize novel bioorthognal chemistries that further expand the utility of this field. Additionally, we explore the utility of fluorescent probes in labeling applications. Finally, we attempt to create novel methods of control for a gene-editing protein using light as a mechanism of regulation.
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Date
2016-05-01
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Undergraduate Honors Theses
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Young, Douglas
McNamara, William
Hinkle, Robert
Saha, Margaret
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Chemistry
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https://scholarworks.wm.edu/handle/internal/12682
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