Thumbnail Image
Publication

Modeling the Effects of Supercomplex Formation and Stress Response on Alzheimer’S Disease Progression

Shelton, Morgan Griffin
Abstract
Alzheimer’s disease is a specific form of dementia characterized by the aggregation of Amyloid-β plaques and tau tangles. New research has found that the formation of these aggregates occurs after dysregulation of respiratory activity and the production of radical oxygen species. Proteomic data shows that these changes are also related to unique gene expression patterns. We investigate the impact of these findings on new therapeutic options via metabolic flux analysis of sirtuin stress response pathways and respiratory supercomplex formation. Our results indicate CRISPR Cas-based gene therapy focused on upregulating stable CIII expression, and protective changes in SIRT1 and AMPK expression are potential avenues for therapeutics. This work also highlights the importance of metabolic enzyme activity in maintaining proper respiratory activity.
Description
Date
2019-01-01
Journal Title
Journal ISSN
Volume Title
Publisher
Collections
Theses & Dissertations
Show all metadata
Download Dataset
Files
Thumbnail Image
Shelton_wmgrad_0261N_10365.pdf
Adobe PDF, 2.75 MB
Rights Holder
Usage License
Embargo
Research Projects
Organizational Units
Journal Issue
Keywords
Citation
Advisor
Coleman, Randolph A
Landino, Lisa M
Kidwell, Nathanael M
Castora, Frank J
Department
Chemistry
DOI
http://dx.doi.org/10.21220/s2-c9zh-am42
URI
https://scholarworks.wm.edu/handle/internal/9127
Embedded videos