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Toward Biologically Active 2,6-Disubstituted Dihydropyran Ring Systems Using an Environmentally Benign Bismuth Catalyst and Mukaiyama Aldol Reaction
Katkish, Lauren
Katkish, Lauren
Abstract
Herein are described optimization studies on the first step of a one-pot, three-component reaction towards biologically active 2,6-disubstituted dihydropyrans (DHPs). Bismuth tribromide proves to be a satisfactory catalyst for a Mukaiyama aldol reaction between an aldehyde or ketone and a silylated enol ether or ketene acetal. This environmentally benign catalyst establishes the viability of a three-component, one-pot reaction toward DHP ring systems, present in anti-cancer, anti-fungal, and anti-osteoporosis agents, among others.
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Thesis is part of Honors ETD pilot project, 2008-2013. Migrated from Dspace in 2016.
Date
2008-05-27
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Keywords
Mukaiyama Aldol, Bismuth Catalysis, 2, 6-Disubstituted Dihydropyran Ring Systems
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Department
Chemistry