Loading...
Genetic Evolution of a Helicobacter pylori Acid-Sensing Histidine Kinase and Gastric Disease
Krishna, Uma Romero-Gallo, Judith Suarez, Giovanni Forsyth, Mark H.
Krishna, Uma
Romero-Gallo, Judith
Suarez, Giovanni
Forsyth, Mark H.
Abstract
Helicobacter pylori is the strongest risk factor for gastric adenocarcinoma, which develops within a hypochlorhydric environment. We sequentially isolated H. pylori (strain J99) from a patient who developed corpus-predominant gastritis and hypochlorhydia over a 6-year interval. Archival J99 survived significantly better under acidic conditions than recent J99 strains. H. pylori arsRS encodes a 2-component system critical for stress responses; recent J99 isolates harbored 2 nonsynonymous arsS mutations, and arsS inactivation abolished acid survival. In vivo, acid-resistant archival, but not recent J99, successfully colonized high-acid-secreting rodents. Thus, genetic evolution of arsS may influence progression to hypochlorhydia and gastric cancer.
Description
Date
2016-01-01
Journal Title
Journal ISSN
Volume Title
Publisher
Collections
Download Dataset
Files
Loading...
genetic.pdf
Adobe PDF, 408.28 KB
Rights Holder
Usage License
Embargo
Research Projects
Organizational Units
Journal Issue
Keywords
Citation
Advisor
Department
Biology
DOI
https://doi.org/10.1093/infdis/jiw189