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Optimization of Solid-Supported Glaser-Hay Reactions in the Microwave

Lampkowski, Jessica S.
; 
Maza, Johnathan C.
; 
Verma, Sanjana
; 
Young, Douglas D.
Abstract
The translation of organometallic reactions into a microwave reactor has numerous advantages. Herein, we describe the application of a previously developed solid-supported Glaser-Hay reaction to microwave conditions. Overall, an array of diynes has been prepared demonstrating the ability to conduct chemoselective reactions in the microwave within 20 min compared to the 16 h thermal conditions. Moreover, non-microwave transparent alkynes have been found to react more quickly, preventing catalyst quenching, and resulting in higher yields.
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2015-01-01
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Chemistry
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Optimization_of_Solid_Supported_Glaser_Hay_Reactions_in_the_Microwave.pdf
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Chemistry
DOI
10.3390/molecules20045276
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https://scholarworks.wm.edu/handle/internal/2028
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