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Tim18p Is a New Component of the Tim54p-Tim22p Translocon in the Mitochondrial Inner Membrane
Kerscher, Oliver Sepuri, Naresh B. Jensen, Robert E
Kerscher, Oliver
Sepuri, Naresh B.
Jensen, Robert E
Abstract
The mitochondrial inner membrane contains two separate translocons: one required for the translocation of matrix-targeted proteins (the Tim23p-Tim17p complex) and one for the insertion of polytopic proteins into the mitochondrial inner membrane (the Tim54p-Tim22p complex). To identify new members of the Tim54p-Tim22p complex, we screened for high-copy suppressors of the temperature-sensitivetim54-1 mutant. We identified a new gene,TIM18, that encodes an integral protein of the inner membrane. The following genetic and biochemical observations suggest that the Tim18 protein is part of the Tim54p-Tim22p complex in the inner membrane: multiple copies of TIM18 suppress thetim54-1 growth defect; thetim18
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2000-01-01
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Biology
DOI
https://doi.org/10.1091/mbc.11.1.103