Date Awarded


Document Type


Degree Name

Doctor of Philosophy (Ph.D.)


Computer Science


Nikos Chrisochoides

Committee Member

Weizhen Mao


Technological Advances in Medical Imaging have enabled the acquisition of images accurately describing biological tissues. Finite Element (FE) methods on these images provide the means to simulate biological phenomena such as brain shift registration, respiratory organ motion, blood flow pressure in vessels, etc. FE methods require the domain of tissues be discretized by simpler geometric elements, such as triangles in two dimensions, tetrahedra in three, and pentatopes in four. This exact discretization is called a mesh . The accuracy and speed of FE methods depend on the quality and fidelity of the mesh used to describe the biological object. Elements with bad quality introduce numerical errors and slower solver convergence. Also, analysis based on poor fidelity meshes do not yield accurate results specially near the surface. In this dissertation, we present the theory and the implementation of both a sequential and a parallel Delaunay meshing technique for 3D and ---for the first time--- 4D space-time domains. Our method provably guarantees that the mesh is a faithful representation of the multi-tissue domain in topological and geometric sense. Moreover, we show that our method generates graded elements of bounded radius-edge and aspect ratio, which renders our technique suitable for Finite Element analysis. A notable feature of our implementation is speed and scalability. The single-threaded performance of our 3D code is faster than the state of the art open source meshing tools. Experimental evaluation shows a more than 82% weak scaling efficiency for up to 144 cores, reaching a rate of more than 14.3 million elements per second. This is the first 3D parallel Delaunay refinement method to achieve such a performance, on either distributed or shared-memory architectures. Lastly, this dissertation is the first to develop and examine the sequential and parallel high-quality and fidelity meshing of general space-time 4D multi-tissue domains.



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