Date Thesis Awarded

5-2018

Document Type

Honors Thesis

Degree Name

Bachelors of Science (BS)

Department

Chemistry

Advisor

Douglas Young

Committee Members

Lisa Landino

Margaret Saha

William McNamara

Abstract

Biconjugate-based therapies are becoming increasingly popular as a drug delivery system. Therefore, the methods for preparing bioconjugates should be sufficiently explored so that bioconjugates can be created in a highly selective, efficient, and robust fashion. This thesis will describe bioconjugation reactions mediated by unnatural amino acids (UAAs) as a means of preparing well-defined and selective macromolecular complexes. Alkyne UAA-mediated bioconjugation reactions will be reported, followed by the results of efforts to prepare multivalent complexes. Lastly, functionalization of a gene-editing protein with UAAs will be explored. The goal of this work is to identify innovative, improved ways of preparing bioconjugates towards downstream applications of enhanced therapeutic delivery.

Available for download on Monday, May 03, 2021

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