Date Thesis Awarded

5-2018

Access Type

Honors Thesis -- Open Access

Degree Name

Bachelors of Science (BS)

Department

Chemistry

Advisor

Douglas Young

Committee Members

Lisa Landino

Margaret Saha

William McNamara

Abstract

Biconjugate-based therapies are becoming increasingly popular as a drug delivery system. Therefore, the methods for preparing bioconjugates should be sufficiently explored so that bioconjugates can be created in a highly selective, efficient, and robust fashion. This thesis will describe bioconjugation reactions mediated by unnatural amino acids (UAAs) as a means of preparing well-defined and selective macromolecular complexes. Alkyne UAA-mediated bioconjugation reactions will be reported, followed by the results of efforts to prepare multivalent complexes. Lastly, functionalization of a gene-editing protein with UAAs will be explored. The goal of this work is to identify innovative, improved ways of preparing bioconjugates towards downstream applications of enhanced therapeutic delivery.

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