Date Thesis Awarded
5-2018
Access Type
Honors Thesis -- Access Restricted On-Campus Only
Degree Name
Bachelors of Science (BS)
Department
Chemistry
Advisor
Douglas Young
Committee Members
Lisa Landino
Margaret Saha
William McNamara
Abstract
Biconjugate-based therapies are becoming increasingly popular as a drug delivery system. Therefore, the methods for preparing bioconjugates should be sufficiently explored so that bioconjugates can be created in a highly selective, efficient, and robust fashion. This thesis will describe bioconjugation reactions mediated by unnatural amino acids (UAAs) as a means of preparing well-defined and selective macromolecular complexes. Alkyne UAA-mediated bioconjugation reactions will be reported, followed by the results of efforts to prepare multivalent complexes. Lastly, functionalization of a gene-editing protein with UAAs will be explored. The goal of this work is to identify innovative, improved ways of preparing bioconjugates towards downstream applications of enhanced therapeutic delivery.
Recommended Citation
Nimmo, Zachary, "Employing Unnatural Amino Acids Towards Therapeutic Bioconjugates" (2018). Undergraduate Honors Theses. William & Mary. Paper 1195.
https://scholarworks.wm.edu/honorstheses/1195
