Date Thesis Awarded
Bachelors of Science (BS)
Christopher J. Abelt
Jianjun Paul Tian
John C. Poutsma
The goal of this study was to synthesize 1-(6-(dimethylamino)naphthalen-2-yl)-2,2-dimethylpropan-1-one, a PRODAN derivative, and perform fluorescence studies comparing the efficacy of various PRODAN derivatives as probes of solvent acidity in HSA. Fluorescence and absorption studies were performed to calculate relative quantum yields of probe-HSA complexes to free probe. Using the relationship between relative quantum yield and solvent acidity, the microacidity in HSA was extrapolated. 3-(dimethylamino)-8,9,10,11-tetrahydro-7H-cyclohepta[a] naphthalen -7-one was determined to be the optimal probe in this study.
Green, Amy Michele, "Synthesis of 1-(6-(dimethylamino)naphthalen-2-yl)-2,2-dimethylpropan-1-one as a Fluorescent Probe of Solvent Acidity in HSA" (2012). Undergraduate Honors Theses. Paper 527.
Creative Commons License
This work is licensed under a Creative Commons Public Domain Dedication 1.0 License.