Date Thesis Awarded


Access Type

Honors Thesis -- Access Restricted On-Campus Only

Degree Name

Bachelors of Science (BS)




Christopher J. Abelt

Committee Members

Jianjun Paul Tian

John C. Poutsma


The goal of this study was to synthesize 1-(6-(dimethylamino)naphthalen-2-yl)-2,2-dimethylpropan-1-one, a PRODAN derivative, and perform fluorescence studies comparing the efficacy of various PRODAN derivatives as probes of solvent acidity in HSA. Fluorescence and absorption studies were performed to calculate relative quantum yields of probe-HSA complexes to free probe. Using the relationship between relative quantum yield and solvent acidity, the microacidity in HSA was extrapolated. 3-(dimethylamino)-8,9,10,11-tetrahydro-7H-cyclohepta[a] naphthalen -7-one was determined to be the optimal probe in this study.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Public Domain Dedication 1.0 License.


Thesis is part of Honors ETD pilot project, 2008-2013. Migrated from Dspace in 2016.

On-Campus Access Only