Loading...
Employing Unnatural Amino Acids Towards Therapeutic Bioconjugates
Nimmo, Zachary
Nimmo, Zachary
Abstract
Biconjugate-based therapies are becoming increasingly popular as a drug delivery system. Therefore, the methods for preparing bioconjugates should be sufficiently explored so that bioconjugates can be created in a highly selective, efficient, and robust fashion. This thesis will describe bioconjugation reactions mediated by unnatural amino acids (UAAs) as a means of preparing well-defined and selective macromolecular complexes. Alkyne UAA-mediated bioconjugation reactions will be reported, followed by the results of efforts to prepare multivalent complexes. Lastly, functionalization of a gene-editing protein with UAAs will be explored. The goal of this work is to identify innovative, improved ways of preparing bioconjugates towards downstream applications of enhanced therapeutic delivery.
Description
Date
2018-05-01
Journal Title
Journal ISSN
Volume Title
Publisher
Collections
Download Dataset
Rights Holder
Usage License
Embargo
Research Projects
Organizational Units
Journal Issue
Keywords
Citation
Department
Chemistry