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Studies Directed Toward the Synthesis of Aristopyridinone A

Leibowitz, Maren K
Abstract
This thesis outlines progress towards the synthesis of aristopyridinone A. Aristopyridinone A is a compound isolated from the traditional Chinese medicine plant Aristolochia manshuriensis. While the plant has been used in a variety of medicinal capacities, the biological activity of aristopyridinone A is unknown. The synthetic pathways presented in this thesis expand on previous work using a merged Diels Alder [4+2] cycloaddition and cycloreversion strategy to form the 2-pyridone core of the aristopyridinone A molecule. These studies also explore the chemistry of the inter-molecular Diels-Alder reaction using a diketopiperazine-derived azadiene.
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2015-04-01
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Undergraduate Honors Theses
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Maren_Leibowitz_Honors_Thesis_Aristopyridinone_A.pdf
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Scheerer, Jonathan
Dalgleish, Harmony
Harbron, Elizabeth
Hinkle, Robert
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Chemistry
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https://scholarworks.wm.edu/handle/internal/11820
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