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Dissociating Alzheimer’s Disease from Amnestic Mild Cognitive Impairment using Time-Frequency Based EEG Neurometrics
Friedl, Wendel Matthew
Friedl, Wendel Matthew
Abstract
This work explores the utility of using magnitude (ERSP), phase angle (ITPC), and cross-frequency coupling (PAC) indices derived from electroencephalogram (EEG) recording using spectral decomposition as unique biomarkers of Alzheimer’s Disease (AD) and amnestic mild cognitive impairment (aMCI), respectively. The experimental protocol was a visual oddball discrimination task conducted during a brief (approximately 20 minute) recording session. Participants were 60 older adults from an outpatient memory clinic diagnosed with either aMCI (n=29; M=73.0; SD=9.32) or AD (n=31; M=78.29; SD=8.28) according to NIA-AA criteria. Results indicate that ITPC values differ significantly between AD and MCI groups. Findings contribute to a growing body of literature seeking to document illness-related abnormalities in time-frequency EEG signatures that may serve as reliable indicators of the pathophysiological processes underlying the cognitive deficits observed in AD and aMCI-afflicted populations.
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2018-01-01
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Department
Psychology
DOI
http://dx.doi.org/10.21220/s2-yck6-d905