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Introducing Additional Protein Functionality via Incorporation of Non-Canonical Amino Acids
Smith, Hannah
Smith, Hannah
Abstract
The incorporation of non-canonical amino acids introduces unique chemical functionality to proteins, enabling the preparation of useful bioconjugates. Bioconjugates have wide applications in disease treatment, imaging, and the improvement of protein stability. We demonstrated the application of non-canonical amino acid-mediated bioconjugation to the immobilization and resulting stabilization of a hyperthermophilic enzyme. Additionally, a bioconjugate capable of detecting prostate cancer was produced. Finally, two methods of preparing multivalent bioconjugates are in progress: one involving the development of a novel non-canonical amino acid and the other involving the adaptation of an organic diyne reaction to a biological setting. This thesis aims to highlight the importance of bioconjugation and expand the applications of bioconjugation for drug development.
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2023-05-01
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2026-05-12
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Chemistry