Loading...
A study of matr3 and its effects on the neural progenitor cells of Xenopus laevis tadpoles
Branham, Kendall
Branham, Kendall
Abstract
Understanding the genes and mechanisms that regulate the highly important process of neurogenesis in the developing nervous system is crucial to uncovering why disease arises when this system is disrupted. Neural progenitor cells and their multipotent nature allow for the growth of a large pool of stem cells in the early stages of development, but the signal that leads these cells to the irreversible fate of becoming a neuron is unclear. The gene matr3 has been implicated in having a role in the maintenance of undifferentiated neural stem cells but its role needs further investigation to fully reveal how its nuclear protein matrin-3 may be affecting this process. Overexpression of this gene through the introduction of plasmid DNA in vivo is expected to maintain the pool of progenitor cells for an extended period of time in the brains of Xenopus laevis tadpoles. Whole brain electroporation and live imaging studies will hopefully reveal the effects of this gene’s overexpression on radial glial progenitor cells within the X. laevis optic tectum and would allow for an increase in the knowledge of how matr3 potentially plays a role in human brain development .
Description
Date
2020-05-01
Journal Title
Journal ISSN
Volume Title
Publisher
Collections
Download Dataset
Rights Holder
Usage License
Embargo
Research Projects
Organizational Units
Journal Issue
Keywords
Citation
Department
Neuroscience