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Investigations of the Fragmentation Spectra of Heptapeptides Containing Lysine and its Non-Protein Amino Acid Homologs

Challener, Douglas William
Abstract
The goal of this experiment was to determine if trends exist in the fragmentation pat- terns of heptapeptides containing lysine and its non-protein amino acid analogs (or- nithine, daba, dapa). Previous research in the laboratory of Dr. J. C. Poutsma on pentapeptides suggested that the length of the side chain on the lysine analog played a role in peptide fragmentation pathways. This study, however, found no such connection between length of side chain and fragmentation patterns suggesting that as a peptide lengthens the flexibility of the peptide bonds outweigh the side chain length factor in determining fragmentation patterns.
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Thesis is part of Honors ETD pilot project, 2008-2013. Migrated from Dspace in 2016.
Date
2010-05-11
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Undergraduate Honors Theses
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ChallenerDouglas2010.pdf
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Keywords
Peptides, Lysine, Fragmentation
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Advisor
Poutsma, John C.
Landino, Lisa M.
Rice, Gary
Tian, Jianjun Paul
Department
Chemistry
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https://scholarworks.wm.edu/handle/internal/12419
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