Loading...
Mechanisms of opioid drug action in the respiratory rhythm-generating preBötzinger complex
Stettler, Marco K
Stettler, Marco K
Abstract
Opioid drugs bind receptors in the brainstem preBötzinger complex (preBötC) to slow the breathing rhythm, but the underlying mechanisms of opioid drug action in the site are poorly understood. Here, we investigate mechanisms in brainstem slices from mice that capture the preBötC and remain rhythmically active in vitro using imaging and electrophysiological approaches. We show that the number of rhythmically active preBötC neurons is not reduced by opioid drugs. We also show that opioid drugs inhibit synaptic release in excitatory terminals within the site. A clearer understanding of how opioid drugs act within the brainstem to depress breathing may guide the development of more effective treatments for opioid-induced respiratory depression.
Description
Date
2025-04-01
Journal Title
Journal ISSN
Volume Title
Publisher
Collections
Download Dataset
Rights Holder
Usage License
Embargo
2035-01-01
Research Projects
Organizational Units
Journal Issue
Keywords
Citation
Department
Neuroscience