Loading...
Synthesis of 1-(6-(dimethylamino)naphthalen-2-yl)-2,2-dimethylpropan-1-one as a Fluorescent Probe of Solvent Acidity in HSA
Green, Amy Michele
Green, Amy Michele
Abstract
The goal of this study was to synthesize 1-(6-(dimethylamino)naphthalen-2-yl)-2,2-dimethylpropan-1-one, a PRODAN derivative, and perform fluorescence studies comparing the efficacy of various PRODAN derivatives as probes of solvent acidity in HSA. Fluorescence and absorption studies were performed to calculate relative quantum yields of probe-HSA complexes to free probe. Using the relationship between relative quantum yield and solvent acidity, the microacidity in HSA was extrapolated. 3-(dimethylamino)-8,9,10,11-tetrahydro-7H-cyclohepta[a] naphthalen -7-one was determined to be the optimal probe in this study.
Description
Thesis is part of Honors ETD pilot project, 2008-2013. Migrated from Dspace in 2016.
Date
2012-07-17
Journal Title
Journal ISSN
Volume Title
Publisher
Collections
Download Dataset
Rights Holder
Usage License
Embargo
Research Projects
Organizational Units
Journal Issue
Keywords
HSA, PRODAN, Solvent acidity
Citation
Department
Chemistry