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Oscillation Regularity in Noise-Driven Excitable Systems with Multi-Time-Scale Adaptation

Nesse, William H
; 
Del Negro, Christopher A
; 
Bressloff, Paul C
Abstract
We investigate oscillation regularity of a noise-driven system modeled with a slow after-hyperpolarizing adaptation current (AHP) composed of multiple-exponential relaxation time scales. Sufficiently separated slow and fast AHP time scales (biphasic decay) cause a peak in oscillation irregularity for intermediate input currents I, with relatively regular oscillations for small and large currents. An analytic formulation of the system as a stochastic escape problem establishes that the phenomena is distinct from standard forms of coherence resonance. Our results explain data on the oscillation regularity of the pre-Bötzinger complex, a neural oscillator responsible for inspiratory breathing rhythm generation in mammals.
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2008-08-22
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Applied Science
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Applied Science
DOI
https://doi.org/10.1103/PhysRevLett.101.088101
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https://scholarworks.wm.edu/handle/internal/1898
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