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Construction of Pyridine Derivatives Using 1,4-Oxazin-2-one Precursors through Cycloaddition / Cycloreversion Tandem Sequences
Carrillo Vallejo, Nicole
Carrillo Vallejo, Nicole
Abstract
This thesis details a novel method for the construction of substituted pyridines using oxazinones in a cycloaddition/cycloreversion tandem sequence. A novel route to the oxazinone precursor is reported, and the reaction scope is explored through reactions with various alkynes. An application of the chemistry to the synthesis of a selective ErbB4 receptor inhibitor is described.
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2021-05-01
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Chemistry