Thumbnail Image
Item

Development of Novel Chemical Strategies to Modulate Biological Function

Uthappa, Diya M
Abstract
This research involves the development of novel chemical strategies to modulate biological function. This approach has taken multiple forms. First, the site-specific incorporation of unnatural amino acids (UAAs) was utilized to develop a novel labeling strategy. Further, the site-specific incorporation of a photocaged UAA was used to control protein activity. Next, solid-supported Glaser-Hay couplings were utilized to efficiently synthesize natural products and to create a library of polyynes, which are molecules containing multiple conjugated acetylenic units. These synthesized molecules were then screened for biological activities. Overall, this thesis discusses the development of these chemical strategies, which contribute additional levels of sophistication to proffer control over biological function. Studying mechanisms to control biological function is critical, as they have potential downstream medical applications in diagnosis, disease prevention, and disease treatment.
Description
Date
2017-05-01
Journal Title
Journal ISSN
Volume Title
Publisher
Collections
Undergraduate Honors Theses
Show all metadata
Download Dataset
Files
Charles_Center_Copy.pdf
Adobe PDF, 2.73 MB
Rights Holder
Usage License
Embargo
Research Projects
Organizational Units
Journal Issue
Keywords
Citation
Advisor
Young, Douglas
Heideman, Paul
Saha, Margaret
Coleman, Randolph
Department
Chemistry
DOI
URI
https://scholarworks.wm.edu/handle/internal/10490
Embedded videos