A Merged Aldol Condensation, Alkene Isomerization, Cycloaddition/Cycloreversion Sequence Employing Oxazinone Intermediates for the Synthesis of Substituted Pyridines
Williamson, Jill B. Smith, Emily R. Scheerer, Jonathan R.
Williamson, Jill B.
Smith, Emily R.
Scheerer, Jonathan R.
Abstract
A domino reaction sequence has been evaluated that begins with union of novel dihydrooxazinone precursors with 2-alkynyl-substituted benzaldehyde components through aldol condensation. Ensuing operations, including alkene isomerization, Diels-Alder, and retrograde Diels-Alder with loss of CO2 occurs in the same reaction vessel to provide polysubstituted tricyclic pyridine products.
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2017-07-01
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Chemistry
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10.1055/s-0036-1588729