Multivalent Conjugation of Biologically Active Molecules Through use of Unnatural Amino Acids
Goff, Cameron
Goff, Cameron
Abstract
While nature has, indeed, worked impressive feats with the 20 canonical amino acids alone, there is room for improvement with intelligent design. With recent developments in the field of genetic engineering, scientist have been able to harness the degeneracy in the genetic code to allow for the integration of unnatural amino acids. These unnatural amino acids provide great promise as analytical probes and tools for the development of therapeutics. To that end the I optimized a multivalent bioconjugation, a series of reactions that couples more than one partner to a biomolecule, with potential therapeutic applications. I also show the utility of unnatural amino acids as molecular probes for analyzing the bioactivity of protein methyltransferase.
Description
Date
2021-05-01