Document Type
Article
Department/Program
Chemistry
Journal Title
Molbank
Pub Date
6-29-2009
Volume
2009
Issue
3
First Page
1
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Abstract
The preparation of 5-bromo-2-naphthol (4) in three steps from 5-amino-2-naphthol (1) is described. A sulfonic acid group is introduced at the 1-position as an activating and protecting group for the Sandmeyer reaction. The sulfonate group allows for the use of only water and sulfuric acid as solvents. The sulfonic acid is introduced with three equivalents of sulfuric acid, and it is removed in 20% aq. sulfuric acid.
Recommended Citation
Abelt, Christopher J., Preparation of 5-Bromo-2-naphthol: The Use of a Sulfonic Acid as a Protecting and Activating Group (2009). Molbank, 2009(3), 1-5.
10.3390/M602
DOI
10.3390/M602
