Document Type
Article
Department/Program
Applied Science
Journal Title
Chaos
Pub Date
2009
Volume
19
Issue
4
Abstract
This paper examines the interplay of the effect of cross immunity and antibody-dependent enhancement (ADE) in multistrain diseases. Motivated by dengue fever, we study a model for the spreading of epidemics in a population with multistrain interactions mediated by both partial temporary cross immunity and ADE. Although ADE models have previously been observed to cause chaotic outbreaks, we show analytically that weak cross immunity has a stabilizing effect on the system. That is, the onset of disease fluctuations requires a larger value of ADE with small cross immunity than without. However, strong cross immunity is shown numerically to cause oscillations and chaotic outbreaks even for low values of ADE. (C) 2009 American Institute of Physics. [doi: 10.1063/1.3270261]
Recommended Citation
Bianco, Simone; Shaw, Leah B.; and Schwartz, Ira B., Epidemics with multistrain interactions: The interplay between cross immunity and antibody-dependent enhancement (2009). Chaos, 19(4).
10.1063/1.3270261
DOI
10.1063/1.3270261
