"Oscillation Regularity in Noise-Driven Excitable Systems with Multi-Ti" by William H. Nesse, Christopher A. Del Negro et al.
 

Document Type

Article

Department/Program

Applied Science

Department

Mathematics

Journal Title

Phys Rev Lett

Pub Date

8-22-2008

Volume

101

Issue

8

Abstract

We investigate oscillation regularity of a noise-driven system modeled with a slow after-hyperpolarizing adaptation current (AHP) composed of multiple-exponential relaxation time scales. Sufficiently separated slow and fast AHP time scales (biphasic decay) cause a peak in oscillation irregularity for intermediate input currents I, with relatively regular oscillations for small and large currents. An analytic formulation of the system as a stochastic escape problem establishes that the phenomena is distinct from standard forms of coherence resonance. Our results explain data on the oscillation regularity of the pre-Bötzinger complex, a neural oscillator responsible for inspiratory breathing rhythm generation in mammals.

DOI

https://doi.org/10.1103/PhysRevLett.101.088101

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