"Optimization of Solid-Supported Glaser-Hay Reactions in the Microwave" by Jessica S. Lampkowski, Johnathan C. Maza et al.
 

Document Type

Article

Department/Program

Chemistry

Journal Title

Molecules

Pub Date

2015

Volume

20

Issue

4

First Page

5276

Abstract

The translation of organometallic reactions into a microwave reactor has numerous advantages. Herein, we describe the application of a previously developed solid-supported Glaser-Hay reaction to microwave conditions. Overall, an array of diynes has been prepared demonstrating the ability to conduct chemoselective reactions in the microwave within 20 min compared to the 16 h thermal conditions. Moreover, non-microwave transparent alkynes have been found to react more quickly, preventing catalyst quenching, and resulting in higher yields.

DOI

10.3390/molecules20045276

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