Date Awarded
2024
Document Type
Thesis
Degree Name
Master of Science (M.Sc.)
Department
Chemistry
Advisor
Douglas Young
Committee Member
Christopher Abelt
Committee Member
Isabelle Taylor
Abstract
Alkynes are valuable synthetic building blocks in organic chemistry and offer crucial reactivity for bioorthogonal chemistry. Herein, this moiety is explored in the context of developing classic small molecule therapeutics, and as a non-canonical amino acid (ncAA) orthogonal handle in bioconjugations. Namely, this functionality was utilized for the production of potent antibiotics, as well as potential biological tools for the diagnosis and treatment of prostate and breast cancer, respectively.
DOI
https://dx.doi.org/10.21220/s2-y0y6-hg22
Rights
© The Author
Recommended Citation
Flood, Brian, "Utilizing Chemical Biology To Develop New Alkyne Therapeutics" (2024). Dissertations, Theses, and Masters Projects. William & Mary. Paper 1727787954.
https://dx.doi.org/10.21220/s2-y0y6-hg22
