Date Thesis Awarded
Honors Thesis -- Open Access
Bachelors of Science (BS)
This project presents a mathematical model of the biochemical pathways involved in remyelination during multiple sclerosis. The model examines several major factors involved in remyelination and their expression over a course of time. This model also highlights processes which are targets for pharmaceutical treatment improving remyelination. The treatments examined include current treatments, drugs being examined for clinical trial, and theoretical treatments. Construction of the model is rooted in Biochemical Systems Theory (BST), which has been successfully applied in the past to examine the biochemistry of neurodegenerative disease. The model uses MATLAB as a means of coding the biochemical pathways into a system of ordinary differential equations (ODEs) producing a qualitative output. Use of MATLAB allows for a variety of treatment states, including use of drug cocktails or delayed onset of treatment.
McGuinness, Matthew J., "A Mathematical Model of Remyelination in Multiple Sclerosis" (2017). Undergraduate Honors Theses. William & Mary. Paper 1114.