Date Thesis Awarded
Honors Thesis -- Open Access
Bachelors of Science (BS)
Deborah C. Bebout
Robert D. Pike, John C. Poutsma
Shantá D. Hinton, William R. McNamara
The recent discovery of a biologically beneficial role for Cd(II) has motivated further investigation of its coordination chemistry. In this work, multidentate ligands model the geometric constraints associated with protein metal binding environments. The synthesis and characterization of Cd(II) complexes in a 1:1 ratio with 2-[[2-(dimethylamino)ethyl]amino]ethanethiol (HL1), Bis(2-methylpyridyl)diselenide (L2), and tris[(1-methyl-2-imidazolyl)methyl]amine (L3) may contribute to a better understanding of potentially biologically relevant interactions between Cd(II) and imidazoles, thiolates, selenoethers and diselenides.
Three new complexes were synthesized and characterized. Electrospray ionization mass spectrometry of [(Cd(L1))6(μ3-CO3)](ClO4)2 demonstrated that aromatic nitrogen donors are an optional component of NNʹS tridentate ligands forming Cd(II) complexes with CO2 fixating properties. The new complex [Cd(L2)(NO3)2] was prepared and characterized by X-ray crystallography, confirming that Cd-(Se2R2) bond formation could be fostered by a chelating ligand. Finally, structural characterization of the new complex [Cd(L3)(NCCH3)](ClO4)2 revealed a great deal of similarity to the coordination environment of Zn(II) in human carbonic anhydrase B.
Rojas Ramirez, Carolina, "Synthesis and Characterization of Cadmium(II) Complexes with Biologically Inspired Multidentate Ligands" (2014). Undergraduate Honors Theses. William & Mary. Paper 112.
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