Date Thesis Awarded

4-2018

Document Type

Honors Thesis

Degree Name

Bachelors of Science (BS)

Department

Chemistry

Advisor

Elizabeth J. Harbron

Committee Members

Christopher J. Abelt

Nathanael M. Kidwell

Alexander B. Angelov

Abstract

We created a system consisting of a highly fluorescent conjugated polymer nanoparticle paired with a photo-release dye. Upon irradiation at the maximum absorbance of the nanoparticle, it non-radiatively transfers its energy to the dye through the process of FRET (Fluorescence Resonance Energy Transfer), exciting the dye, which then releases a biologically relevant ion, zinc. This system enhances the photo-release process, making it kinetically faster and more efficient. The photo-event is accompanied by a change in fluorescence of the dye, allowing for simultaneous detection of photo-release. This thesis outlines nanoparticle synthesis using the reprecipitation method, synthesis of the zinc releasing dye, and nanoparticle doping procedure.

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