Date Thesis Awarded
Honors Thesis -- Open Access
Bachelors of Science (BS)
This thesis outlines progress towards the synthesis of aristopyridinone A. Aristopyridinone A is a compound isolated from the traditional Chinese medicine plant Aristolochia manshuriensis. While the plant has been used in a variety of medicinal capacities, the biological activity of aristopyridinone A is unknown. The synthetic pathways presented in this thesis expand on previous work using a merged Diels Alder [4+2] cycloaddition and cycloreversion strategy to form the 2-pyridone core of the aristopyridinone A molecule. These studies also explore the chemistry of the inter-molecular Diels-Alder reaction using a diketopiperazine-derived azadiene.
Leibowitz, Maren K., "Studies Directed Toward the Synthesis of Aristopyridinone A" (2015). Undergraduate Honors Theses. William & Mary. Paper 232.
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