Date Thesis Awarded
Honors Thesis -- Access Restricted On-Campus Only
Bachelors of Science (BS)
Robert Michael Lewis
Gregory D. Smith
Jianjun Paul Tian
Mitochondria have been proposed to be an integral part of intracellular calcium signaling. We examine the two-pool model of intracellular calcium signaling by Goldbeter et al. 1990  and propose a new model that uses the mitochondria. This creates a three-pool model for intracellular calcium signaling. We then proceed to discuss the differences between the two-pool and three-pool models by following the analysis of the two-pool model presented by Sneyd et al. 1993 . The addition of the third pool does not change any of the dynamics of the two-pool model, but adds some functionality. The mitochondria acts like a buffer that has the ability to change the temporal dynamics, and we have a region of bistability that allows for dampened oscillations given the right stimulus and initial conditions.
Hariprasad, Daniel, "Three Pool Model of Calcium Signaling" (2009). Undergraduate Honors Theses. William & Mary. Paper 259.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
On-Campus Access Only