Date Thesis Awarded
Honors Thesis -- Access Restricted On-Campus Only
Bachelors of Science (BS)
Robert J. Hinkle
Kurt E. Williamson
Outlined in this paper is a series of work done towards the construction of bicyclo[2.2.2]diazaoctane structures found in a several natural products. Detailed work is shown for a general method of creating these cores by a domino sequence to rapidly generate these cores with enantio- and diastereoselectivity. A similar sequence this outlined and displayed in the formal synthesis of brevianamide B. This synthesis makes use of a similar domino sequence, but a new source of facial selectivity is used.
Chinn, Alex, "Methodology towards the Construction of Bicyclo[2.2.2]diazaoctane Cores and its Application Towards the Synthesis of Brevianamide B" (2013). Undergraduate Honors Theses. William & Mary. Paper 770.
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