Date Thesis Awarded

5-2008

Document Type

Honors Thesis

Degree Name

Bachelors of Science (BS)

Department

Chemistry

Advisor

Robert J. Hinkle

Committee Members

Christopher J. Abelt

Lisa M. Landino

Rene S. Cabral-Daniels

Abstract

Herein are described optimization studies on the first step of a one-pot, three-component reaction towards biologically active 2,6-disubstituted dihydropyrans (DHPs). Bismuth tribromide proves to be a satisfactory catalyst for a Mukaiyama aldol reaction between an aldehyde or ketone and a silylated enol ether or ketene acetal. This environmentally benign catalyst establishes the viability of a three-component, one-pot reaction toward DHP ring systems, present in anti-cancer, anti-fungal, and anti-osteoporosis agents, among others.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

Comments

Thesis is part of Honors ETD pilot project, 2008-2013. Migrated from Dspace in 2016.

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