Title
Kinomic exploration of temozolomide and radiation resistance in Glioblastoma multiforme xenolines
Document Type
Article
Department/Program
General Education
Journal Title
Radiotherapy and Oncology
Pub Date
5-8-2014
Volume
111
Issue
3
Journal Article URL
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119546/
First Page
468
Abstract
Glioblastoma multiforme (GBM) represents the most common and deadly primary brain malignancy, particularly due to temozolomide (TMZ) and radiation (RT) resistance. To better understand resistance mechanisms, we examined global kinase activity (kinomic profiling) in both treatment sensitive and resistant human GBM patient-derived xenografts (PDX or “xenolines”).
Recommended Citation
Anderson, Joshua C.; Duarte, Christine W.; Welaya, Karim; Rohrbach, Timothy; Bredel, Markus; Yang, Eddy S.; Choradia, Nirmal; Thottassery, Jaideep V.; Gillespie, G. Yancey; Bonner, James A.; and Willey, Christopher D., "Kinomic exploration of temozolomide and radiation resistance in Glioblastoma multiforme xenolines" (2014). Richard Bland Faculty Works. 12.
https://scholarworks.wm.edu/rbc_facwork/12
DOI
https://doi.org/10.1016/j.radonc.2014.04.010
Publisher Statement
Radiother Oncol. Author manuscript; available in PMC 2015 Jun 1. Published in final edited form as: Radiother Oncol. 2014 Jun; 111(3): 468–474. Published online 2014 May 8. doi: 10.1016/j.radonc.2014.04.010
