Document Type
Article
Department/Program
Virginia Institute of Marine Science
Publication Date
2020
Journal
Journal of Aquatic Animal Health
Abstract
Vaccine efficacy in preventing clinical disease has been well characterized. However, vaccine impacts on transmission under diversefied conditions, such as variable pathogen exposure dosages, are not fully understood. We evaluated the impacts of vaccination on disease-induced host mortality and shedding of infectious hematopoietic necrosis virus (IHNV) in Rainbow Trout Oncorhynchus mykiss. Fish, in up to three different genetic lines, were exposed to different dosages of IHNV to simulate field variability. Mortality and viral shedding of each individual fish were quantified over the course of infection. As the exposure dosage increased, mortality, number offish shedding virus,daily virus quantity shed, and total amount of virus shed also increased. Vaccination significantly reduced mortality but had a much smaller impact on shedding, such that vaccinated fish still shed significant amounts of virus, particularly at higher viral exposure dosages. These studies demonstrate that the consideration of pathogen exposure dosage and transmission are critical for robust inference of vaccine efficacy.
DOI
DOI: 10.1002/aah.10108
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Jones, Darbi R.; Rutan, Barbara J.; and Wargo, AR, Impact of Vaccination and Pathogen Exposure Dosage on Shedding Kinetics of Infectious Hematopoietic Necrosis Virus (IHNV) in Rainbow Trout (2020). Journal of Aquatic Animal Health.
DOI: 10.1002/aah.10108
Supplementary material
