Date Thesis Awarded
Honors Thesis -- Access Restricted On-Campus Only
Bachelors of Science (BS)
Greg Conradi Smith
Hybridization between species, by introducing dramatic trait variation into the population and creating viable, transgressive offsprings with novel phenotypes, can have huge evolutionary implications. Some hybrid traits have been studied in the classical genetics or population genetics context, but most complex traits are determined by multiple causes, e.g. the number of loci involved, the rewiring of the genetic circuitries, and the changes in gene expression pattern. Using the hybrid monkeyflower petal pigment patterning as an example, we present a case study to investigate complex hybrid traits in a systematic manner that includes empirical data analysis and quantitative mathematical modeling of the petal spot patterning trait in the F2 population. We identified candidate loci for a potential Turing-like dynamics that regulate the trait and simulated a 2-D F2 trait space with hybrid genetics assumptions that determine the pattern variations. Our study provides a fresh angle to study complex hybrid traits, and the workflow can be applied to other similar systems.
Zheng, Xingyu, "Modeling Hybrid Novel Traits: A case study in complex petal pigment patterning in hybrid Mimulus" (2020). Undergraduate Honors Theses. William & Mary. Paper 1492.
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