Date Thesis Awarded
5-2021
Access Type
Honors Thesis -- Access Restricted On-Campus Only
Degree Name
Bachelors of Science (BS)
Department
Chemistry
Advisor
Jonathan Scheerer
Committee Members
Elizabeth Harbron
Mark Forsyth
Abstract
This thesis details a novel method for the construction of substituted pyridines using oxazinones in a cycloaddition/cycloreversion tandem sequence. A novel route to the oxazinone precursor is reported, and the reaction scope is explored through reactions with various alkynes. An application of the chemistry to the synthesis of a selective ErbB4 receptor inhibitor is described.
Recommended Citation
Carrillo Vallejo, Nicole, "Construction of Pyridine Derivatives Using 1,4-Oxazin-2-one Precursors through Cycloaddition / Cycloreversion Tandem Sequences" (2021). Undergraduate Honors Theses. William & Mary. Paper 1609.
https://scholarworks.wm.edu/honorstheses/1609
