Date Thesis Awarded

5-2024

Access Type

Honors Thesis -- Access Restricted On-Campus Only

Degree Name

Bachelors of Science (BS)

Department

Neuroscience

Advisor

Randolph Coleman

Committee Members

Jennifer Bestman

Christy Porter

Abstract

Brain-derived neurotrophic factor (BDNF) is an endogenously produced neurotrophin that modulates neuronal survival, plasticity, differentiation, and health of synapses in the central nervous system. Neurodegenerative diseases, such as Alzheimer’s Disease (AD) and Parkinson’s Disease (PD), disrupt these vital processes, marked by progressive loss of neuronal structure or function and the abnormal accumulation of specific proteins detrimental to brain health. The diminished expression of BDNF can further exacerbate these dysfunctions in neurodegenerative diseases. These diseases require effective therapies to manage the challenges faced by those affected. One prominent therapy involves the use of BDNF. Notably, physical exercise emerges as a protective intervention, exhibiting synaptic and neural protection, with BDNF serving a key role in facilitating exercise-induced improvements in cognitive function. This paper explores the mechanisms by which exercise upregulates BDNF production and its impacts on the pathology of neurodegenerative diseases.

Using CellDesigner to create biochemical network diagrams and COPASI to evaluate these pathways, we tested the neuroprotective implications of BDNF from exercise. We found that exercise-induced production of BDNF exhibits significant improvements in synaptic and neuronal function, demonstrating its role as a potential therapeutic. The beneficial effects of BDNF highlights the potential of lifestyle modifications to serve as a mitigating factor in the development and progression of neurodegenerative diseases.

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