Date Thesis Awarded
Honors Thesis -- Access Restricted On-Campus Only
Bachelors of Science (BS)
Christopher J. Abelt
Lisa M. Landino
The goal of study was to explore the synthesis of 1-(5-methylhexyl)-2,3,8,9-tetrahydro-1H-naphtho[2,1-e]indol-6(7H)-one. This molecule is designed to act as a fluorescent model for cholesterol. It mimics cholesterol in terms of size, shape, and hydrophobic nature. . A nine-step synthesis was explored in order to develop this model. 1-(5-methylhexyl)-2,3,8,9-tetrahydro-1H-naphtho[2,1-e]indol-6(7H)-one was designed to be used as a cholesterol model in order to explore the cholesterol binding sites of the protein human serum albumin.
Lopez, Nicholas, "Synthesis of 1-(5-methylhexyl)-2,3,8,9-tetrahydro-1H-naphtho[2,1-e]indol-6(7H)-one" (2011). Undergraduate Honors Theses. William & Mary. Paper 361.
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On-Campus Access Only
Thesis is part of Honors ETD pilot project, 2008-2013. Migrated from Dspace in 2016.