Document Type

Article

Department/Program

Virginia Institute of Marine Science

Publication Date

1999

Journal

Bulletin of the European Association of Fish Pathologists

Volume

19

Issue

6

First Page

245

Last Page

249

Abstract

Teleosts possess mechanism(s) by which they can generate considerable structural diversity within their tetrameric antibody molecules. In salmonids, this diversity is generated through a process of random polymerisation of the constituent monomeric subunits rather than dependency upon isotypic gene diversity. Thus, one gene product can give rise to as many as six different structural forms of immunoglobulin. In contrast to mammals, evidence suggests that this polymerisation process occurs late in the secretory process and not within the endoplasmic reticulum. This assembly process is likely to be important in the generation of teleost antibody functional diversity, thereby potentially simulating isotypy.

Keywords

Monoclonal-Antibodies; Atlantic Salmon

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