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Honors Theses from 2024

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A Unified Synthetic Approach to Onychine, Eupolauridine, and 1-Azafluoranthene via A Shared 1,2,4-Triazine Precursor, Yun Ma

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Development of Low-Cost, Arduino based, Nephelometric and Back-Scatter Turbidity Sensors for Community-Led Environmental Restoration Monitoring in Rural Alaotra-Mangoro Region, Madagascar and James City County, Virginia, Sophia Holincheck

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Harnessing the Power of Virtual Reality for Organic Chemistry Education, Jungmin Shin

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IMPACT OF INTERFACIAL SOLVATION ENVIRONMENTS ON NITROPHENOL PHOTOCHEMISRY, W. Churchill Wilkinson

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Investigating Organic Fluorophores for Blink-Based Multiplexing, Amelia Seabury

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Investigation into Amine Polyynes for Antibacterial Properties, Sage Kregenow

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Metal Antipyrine Complexes for Hydrogen Evolution and Oxygen Reduction, Nicole A. Fritsch

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Molecular Dynamics simulations of Solid-Liquid Interfaces for NMR Relaxometry, Jacob Simonpietri

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Non-Canonical Amino Acids for Multivalent Conjugation and Light-Mediated Protein Modulation, Robert Kinsman Gourdie

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Optimizing Single-Molecule Blink-Based Multiplexing, Emma Smith

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Process Modeling the Neuroprotective Effects of a Plant-Based Diet on Parkinson's Disease, Julia Mitchell

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Proton Affinities for Proline and Pipecolic-Acid Containing Dipeptides, Georgia Westbrook

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Self-Reporting Conjugated Polymer Nanoparticles for Superoxide Generation and Detection, Anna Clayborn

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Synthesis of Pyridine Derivatives: Cycloaddition/Cycloreversion of 1,4-Oxazinone Intermediates, Zannatul Shahla

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Understanding and Harnessing the Blinking Behavior of Emitters for Single-Molecule Imaging, Isabelle Kogan

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Use of Molecular Logic Gates for the Tuning of Chemosensor Dynamic Range, Orhan Acikgoz

Honors Theses from 2023

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A Combinatorial and Solution Phase Approach to the Synthesis of Polyyne Compound Libraries with Therapeutically Relevant Biological Activity., Cody Funk

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Development of Data Science Tools for Photovoltaic Design and Super-Resolution Imaging, Grayson Hoy

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Examining the Nutritional Quality of Mixotrophic Dinoflagellates Using Elemental Ratios and Total Lipid Content, Delaney Kirr

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First Row Metal Complexes for the Hydrogen Evolution Reaction of Artificial Photosynthesis, Ryan Anderson

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Introducing Additional Protein Functionality via Incorporation of Non-Canonical Amino Acids, Hannah Smith

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Modulation of Protein Function and Synthesis of Bioconjugates using Unnatural Amino Acids, Naya Burrow

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Solvent-Mediated Photophysical Outcomes of Brown Carbon Chromophores, Ruby Neisser

Honors Theses from 2022

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Chemical Analysis of Organic Compounds in Dew Water, Monica Dibley

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Copper(I) Iodide Complexes for the Detection of Aqueous Pyridine, Stephen Yachuw

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Differential Protein Expression in Bacteriophages CrimD and Larva, Daria Moody

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Gas-Phase Proton Affinities for Twenty of the Proline-Containing Dipeptides, Henry Cardwell

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I. Synthesis of Pyrrolodiketopiperazines from an Intact Diketopiperazine Ring II. A Non-oxidative Method for Synthesizing 1,2-diketones from Aldehyde and Organometallic Building Blocks, Gwyneth Pudner

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SERS Analysis of Pretreated Red Lake Colorants in Historical Oil Paintings & Development of a SERS Spectral Analysis Program with Deep Learning, Zhaoyun Zheng

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Synthesis and Biological Testing of Small-Molecule Mitochondrial Complex I Inhibitors, Willough Sloan

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The Role of Relative Humidity on Biomass Burning Organic Aerosol Photolysis, Natalie Warren

Honors Theses from 2021

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Alkylpyridinium Iodobismuthate Structural Determination and Analysis, Neal Marshall

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Construction of Pyridine Derivatives Using 1,4-Oxazin-2-one Precursors through Cycloaddition / Cycloreversion Tandem Sequences, Nicole Carrillo Vallejo

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Developing Iron Complexes for Electrocatalytic Hydrogen Generation, Benjamin Travis

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Experimental and Computational Electronic Quenching Dynamics of Nitric Oxide by Molecular Collisional Partners, David J. Hood

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Humic Acids as Sacrificial Electron Donors for Photocatalytic Hydrogen Generation, Allison Moyer

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Investigating Charge Transfer Complexes in Brown Carbon Aerosols, Brianna Peterson

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Molecular Cluster Fragment Machine Learning Training Techniques to Predict Energetics of Brown Carbon Aerosol Clusters, Emily E. Chappie

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Multivalent Conjugation of Biologically Active Molecules Through use of Unnatural Amino Acids, Cameron Goff

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Photolysis of Methylglyoxal Brown Carbon, Lemai Vo

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Proteomic Analysis of Mycobacteriophage CrimD, William Moeller

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Spectroscopy and Dynamics of CO-NO: Intermolecular Interactions Drive Photochemical Outcomes, Daniel Costantino

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Synthesis and Biological Testing of Quinone-Based Natural Products, Yihan Qin

Honors Theses from 2020

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Adaptation of a Low-Cost Hyperpolarization Technique for Use with Single-Sided NMR, Ruth A. Beaver

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Chemical Transformation of Biomass Burning Organic Aerosols Due to Photolytic Aging, Hongmin Yu

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Conformational Changes of Lactate Dehydrogenase Isozymes, Benjamin Hauk

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Determination of Thermodynamic Properties of Non-Protein Amino Acids and Characterization of Multimers of Carbamazepine, Gwendylan Turner

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Employing Unnatural Amino Acids to Develop Bioconjugations, Multivalent Conjugates, and Protein Modulation Strategies, Elizabeth King

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Iron polypyridyl complexes for electrocatalytic proton reduction, Zachary Schiffman

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Photocatalytic Generation of Hydrogen Catalyzed by Iron (III) Polypyridyl Complexes, Margaret Lawrence

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Photolytic Aging of 4-Nitrophenol: Effects of Fresh and Aged Secondary Organic Aerosol on Atmospheric Lifetimes, Lydia Dolvin

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Study of the Catalytic Abilities of Methyl-Functionalized & Dimethyl-Functionalized Iron Complexes for Proton Reduction, Jiashu Wang

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Synthesis and Investigation of Asymmetric Diyne and Polyyne Compounds for Biological Activity, Lauren Mazur

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Using Unnatural Amino Acid Technologies to Immobilize and Regulate Proteins, Emily Mae Peairs

Honors Theses from 2019

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1,4-Benzoquinone and 1,4-Naphthoquinone Natural Products: C-H Functionalization and Enzymatic Activity, Zhenyu Han

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Atomic Force Microscopy Measurements of Interfacial Forces Between Boron Nitride and Polymers for Development of an Optimum Nano-Composite, Hall Zhang

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Characterizing Flame-resistant Polymers using Single-sided NMR, Anna Tsutsui

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Determinations of Proton Affinities of Methylated Cysteine and Serine Homologs, Danielle Long

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Electrocatalysis for Proton and Oxygen Reduction Reactions, William Lake

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Exploring the Blinking Dynamics of Eosin Y Photosensitizers for Dye-Sensitized Photocatalysis Using Single-Molecule Spectroscopy, Pauline Lynch

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Iron Complexes for Photocatalytic Hydrogen Generation, Indira Stevens

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Optimizing Silver Nanoparticles for Pigment Identification in Art, Carolyn Farling

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Spatial Encoding with Single-sided NMR, Madeline Brass

Honors Theses from 2018

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Accessing Light-Sensitive Polycyclic Aromatics through an Alkynyl-Prins Cyclization, Daniel John Speer

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Alkyl Arylinium Iodocuprate Clusters: Structural and Spectroscopic Diversity, Amelia Marie Wheaton

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Characterizing the Ductile-Brittle Transition of Polyamide-11/ Purification and Characterization of Boron Nitride Nanotubes, William Kim

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Construction of Bicyclo[2.2.2]diazaoctane Scaffolds via Intermolecular Diels-Alder: Synthesis of (±)-Brevianamide B and Progress Toward (+)-Serantrypinone, Xiye Wang

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Development and Optimization of Bioconjugations to Probe and Modulate Protein Function, Christopher Travis

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Employing Unnatural Amino Acids Towards Therapeutic Bioconjugates, Zachary Nimmo

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Gas-Phase Hydrogen-Deuterium Exchange and Fragmentation Studies of Tetrapeptides Containing Lysine and Its Homologs, AnnaTram Do

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Imaging the Dynamics of CH2BrI Photodissociation in the Near Ultraviolet Region, Changen Pan

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Investigation of the Catalytic Ability of Iron Complexes Containing Pendant Proton Relays for Proton Reduction, Shichuan Xi

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Photo-Controlled Release of Zinc Ions in Aqueous Solution with Simultaneous Fluorescence Detection, Tyler Larson

Honors Theses from 2017

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Advancements in the Photocatalysis of Iron Complexes and the Electrocatalysis of Cobalt Complexes for Hydrogen Generation, Ryan J. DiRisio

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An analysis of oxidative damage to lactate dehydrogenase in context of neurodegeneration and catechol-based phenolic antioxidant chemistry, Lydia Boike

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Characterization of Mixed N,S Donor Ligand and Group 12 Metal Complexes with X-Ray Crystallography, ESI-MS, and NMR, Mikhaila D. Ritz

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Connecting Energy Metabolism and Neurodegeneration: Pyruvate Kinase and Oxidative Stress, Julia P. Zuercher

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Development of Novel Chemical Strategies to Modulate Biological Function, Diya M. Uthappa

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Does 5-propionyl-1-dimethylaminonapthalene Fluoresce through a TICT State?, Tao Chen

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Electrocatalytic Hydrogen Generation by Cobalt Complexes, Jessica E. Armstrong

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Fluorescently-Labeled Glutathiones to Quantify Cysteine Reactivity, Saloni H. Patolia

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Improving Water Barrier Properties of Epoxy Coatings with Addition of Graphene Oxide, Sang H. Kim

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Investigating Biological Properties Utilizing Synthetic Methods, Lindsay E. Chatkewitz

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Metabolism and Oxidative Stress: Understanding the Role of Reactive Cysteines in Pyruvate Kinase, Mary Cate Duff

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Metabolism and Oxidative Stress: Understanding the Role of Reactive Cysteines in Pyruvate Kinase, Mary Cate Duff

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Optogenetic Investigations of the PreBötzinger Complex: Support for the Dbx1 Core Hypothesis, Francis D. Pham

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Photocontrol of pH via Doped Conjugated Polymer Nanoparticles, Aaron I. Bayles

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Structural Comparison of Copper(II) Thiocyanate Pyridine Complexes, Joseph V. Handy

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Total synthesis of barettin: Model study of specialized aldol condensation to directly access diketopiperazine targets, Elizabeth W. Kelley

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Towards a Greater Understanding of Post-Translational Modification of Transcription Factor, ArsR, in Helicobacter pylori via Bottom-Up Proteomics: Methods Development for Electrospray and Nanospray Approaches, Theresa Gozzo

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Tuning the pKa of Fluorescent Rhodamine pH Probes via Substituent Effects, Sarah G. Stratton

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Utilization of Unnatural Amino Acids in Novel Bioconjugates and Probing Applications, Christina A. Howard

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Visible Light Fluorescence Switching in Dye-Doped Conjugated Polymer Nanoparticles, Xinzi Zhang

Honors Theses from 2016

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An Experimental and Theoretical Study of Proton Affinity in Proline-Containing Dipeptides: Exploring the “Proline Effect”, Anton Luke Lachowicz

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Construction of Bicyclo[2.2.2]diazaoctane Alkaloids via Intermolecular [4+2] Cycloadditions, Jacob Gabriel Robins

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Creating a Computational Model of Prion Disease in the Human Neocortex, Christina Alexandra Stephens

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Domino Reactions Involving Merged Cycloaddition and Cycloreversion Processes Affording Pyridine Products, Jill Williamson

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Fragmentation Studies of Lysine and Lysine Analog Containing Tetrapeptides, Zachariah Imran Hasan

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Hydrogen-Bonding Control of Solvatochromism and Non-Radiative Decay in the Fluorescence of 3-Aminofluoren-9-one Derivatives, Isaac Gregory Alty

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Investigation of Unnatural Amino Acids as a Means to Modulate Protein Function, Taylor Harrison Jacobs