Date Thesis Awarded
5-2009
Access Type
Honors Thesis -- Access Restricted On-Campus Only
Degree Name
Bachelors of Science (BS)
Department
Chemistry
Advisor
Robert J. Hinkle
Committee Members
David W. Thompson
Lisa M. Landino
Matthew J. Wawersik
Abstract
BiBr3 and Bi(OTf)3 have proven to be effective catalysts for Mukaiyama aldol reactions and Intramolecular silyl-Modified Sakurai (ISMS)/silyl-Prins type reactions towards cis-2,6-disubstituted-3,4-dihydropyrans. Herein are described studies towards the use of these Bi(III) salts in multi-component reactions to afford cyclic ethers, a structural motif found in natural products, such as the diospongins, which have been reported to posses potential therapeutic value. These investigations have also attempted to shed light on the ambiguity surrounding the method of action behind Bi(III) salts' catalytic power.
Recommended Citation
Speight, Lee Colyer, "Bismuth(III) Catalyzed Cyclic Ether Syntheses" (2009). Undergraduate Honors Theses. William & Mary. Paper 294.
https://scholarworks.wm.edu/honorstheses/294
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Comments
Thesis is part of Honors ETD pilot project, 2008-2013. Migrated from Dspace in 2016.